WebDec 7, 2024 · In addition, TTK has been discovered to function as an oncogene in various cancers [12,13,14, 18,19,20,21], and TTK inhibition has already been studied as a targeted … WebDec 1, 2024 · Differential genes associated with Gleason score were selected and filtered out by p < 0.05 and spearman coefficient >0.3. KEGG signaling pathway was enriched by …
TTK promotes mesenchymal signaling via multiple mechanisms in …
WebApr 12, 2024 · Zhu, D. et al. Synthetic lethal strategy identifies a potent and selective TTK and CLK1/2 inhibitor for treatment of triple-negative breast cancer with a compromised G … WebTTK has emerged as a promising therapeutic target in human cancers, including triple-negative breast cancer (TNBC). Several TTK inhibitors (TTKis) are being evaluated in clinical trials, and an understanding of the mechanisms mediating TTKi sensitivity and resistance could inform the successful development of this class of agents. great hub city
Integrated multi-omics analyses and functional validation reveal TTK …
WebIn addition, TTK was overexpressed in different solid tumor types, suggesting its importance in cancer progression (SI Appendix, Fig. S1). Further, OncoPrint analysis showed that TTK over-expression was the most significantly associated with mutations and deletions in TP53 and PTEN, the two commonly altered tumor suppressor genes and negative cell-cycle … WebApr 23, 2024 · TTK acted as an oncogene in liver cancer and indicator of poor survival prognosis. • TTK inhibitor increase radiosensitivity in liver cancer. • TTK inhibitor promote liver cancer cells to accumulate in the G2/M phase. • TTK inhibitor enhances DNA damage with more γ-H2AX foci and more apoptosis and necrosis induced by radiation. • WebMay 20, 2013 · Triple-negative breast cancer (TNBC) represents a subgroup of breast cancers (BC) associated with the most aggressive clinical behavior. No targeted therapy is currently available for the treatment of patients with TNBC. In order to discover potential therapeutic targets, we searched for protein kinases that are overexpressed in human … greathub