2024 Klf2 macrophage

Klf2 macrophage

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August undefined, 2024

WebJul 1, 2011 · Krüppel-like factor 4 regulates macrophage polarization - PMC Back to Top Skip to main content An official website of the United States government Here's how you know The .gov means it’s official. Federal government websites often end in .gov or .mil. sharing sensitive information, make sure you’re on a federal WebJun 29, 2024 · Immune-regulatory mechanisms of drug-free remission in rheumatoid arthritis (RA) are unknown. We hypothesized that synovial tissue macrophages (STM), which persist in remission, contribute to ...

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WebKLF2 can also promote the differentiation and function of B-cell through promoting CD62L, CXCR7, and β7-integrins expression [29]. ... has the function of anti-inflammation and anti-thrombotic through regulating the reaction between endothelial cells and macrophages in the case of atherosclerosis via the Ch25h/LXR axis [6], [34]. WebApr 9, 2024 · KLF2 KLF transcription factor 2 [ (human)] Gene ID: 10365, updated on 21-Mar-2024 Summary This gene encodes a protein that belongs to the Kruppel family of transcription factors. The encoded zinc finger protein is expressed early in mammalian development and is found in many different cell types. flybat lifepo4 app

Calenduloside e modulates macrophage polarization via KLF2 …

WebMar 21, 2024 · MEF2 intervened LPS-induced acute lung injury by binding to KLF2 promoter and modulating macrophage phenotype. Renoprotective Effect of KLF2 on Glomerular … WebApr 1, 2024 · Previous studies have shown that KLF2 is necessary for regulating glycolytic flux. In this study, we overexpressed KLF2 in macrophages to investigate whether KLF2 … WebMay 1, 2024 · Klf2 Ldlr Lif Lox Lpl Ltbp2 Mmp2 Mmp3 Mmp9 Msr1 Nfkb1 Npy Pdgfa Pdgfb Pdgfrb Plin2 Ppara Ppard Pparg Sele Sell Selp Selplg Serpinb2 Serpine1 Smad3 Smad4 Spp1 Tgfb1 Tgfb2 Tgfbr1 Timp1 Tnc ... Macrophage scavenger receptor 1 Nuclear factor κ B subunit 1 Neuropeptide Y Platelet-derived growth factor subunit A flybath towel rail

Myeloid-Specific Krüppel-Like Factor 2 Inactivation Increases ...

Establishment of bone marrow-derived M-CSF receptor

WebApr 1, 2024 · CE inhibits glycolysis-mediated M1 macrophage polarization by upregulating KLF2 expression in RAW 264.7 macrophages. (a, b) The expression of KLF2 in RAW 264.7 macrophages treated with siRNA control or si-KLF2 was analyzed by western blotting analysis (n = 3). (c, d) Representative photographs and statistical results of PFKFB3, … WebOct 31, 2024 · KLF2 alleviates endothelial cell injury and inhibits the formation of THP‑1 macrophage‑derived foam cells by activating Nrf2 and enhancing autophagy Atherosclerosis (AS) is an important cause of common vascular diseases. fly bat gliderWebApr 30, 2024 · Here, we identify myeloid Krüppel-like factor 2 (KLF2) as an essential regulator of obesity and its sequelae. In mice and humans, … greenhouse gas protocol categories

"WebDec 28, 2024 · klf2 klf2 expression in endothelium, but not myocardium, prevents this cardiomyocyte extrusion phenotype. Transcriptome analysis of klf2 mutant hearts reveals that Fgf signaling is affected, and accordingly, we find that inhibition of Fgf signaling in wild-type animals can lead to abluminal cardiomyocyte extrusion. " - Klf2 macrophage

Klf2 macrophage

Myeloid KLF2 regulates a macrophage-enriched …

WebJun 5, 2024 · For isolation of adipose tissue macrophages, adipocytes, and stromal vascular cells (SVCs), adipose tissues isolated from mice were minced into fine pieces immediately after CO 2 asphyxiation and... WebOct 10, 2024 · A boxplot of downregulated genes DUSP1, KLF2, PMP22, and ZEB2 was shown. That raised an interesting question about the pathological meaning of downregulated top gene markers. Actually, some markers like ZEB2 exhibited a rather unique expression in macrophages according to the EC1 UMAP plot.

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WebFeb 5, 2024 · KLF2 is a member of the Kruppel-like transcription factor family of proteins containing highly conserved DNA-binding zinc finger domains. KLF2 participates in the differentiation and regulation of the functional activity of monocytes, T lymphocytes, adipocytes, and vascular endothelial cells. The activity of KLF2 is controlled by several … WebNov 21, 2024 · Cues from the tissue microenvironment program macrophages for silent AC clearance • KLF2 and KLF4 control expression of genes necessary for silent AC clearance …

WebJun 11, 2024 · KLF2 inhibits NF-κB-dependent proinflammatory activation of macrophages ( 56, 57 ). By contrast, KLF6 acts cooperatively with NF-κB to promote proinflammatory … WebApr 1, 2024 · Chromatin immunoprecipitation assays demonstrated that Klf4, Klf2, and Zfp148 separately bind autophagy genes in smooth muscle cells following elastase treatment. ... In immunostaining, macrophages, T cells, neutrophils, and neovessels were significantly reduced in aorta of spermidine-treated, as compared with vehicle-treated …

WebOct 28, 2024 · In macrophages of the plaque, KLF2 expression was increased, whereas the MLKL expression was decreased after long-term calycosin administration (Figure 6a). … WebAdditionally, antiatherogenic properties of KLF2 appear to be mediated through its effects on lymphocyte and monocyte/macrophage biology. KLF2 has important roles in embryonic and adult vasculogenesis and angiogenesis under physiological and pathological conditions and plays a key role in embryonic heart valve formation. Recent data show that ...

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WebMyeloid KLF2 regulates a macrophage-enriched metabolic network and is responsive to metaflammatory stress a Gene-set enrichment analysis of bone marrow-derived macrophages (BMDMs) from... fly bateWebMar 4, 2024 · KLF2 resisted inflammation within macrophages and inhibited M1-type macrophage polarization by recruiting NF-κB cofactors away from the promoters of inflammatory genes . Here, we discovered a novel mechanism involving the inhibition of HSPH1 gene transcription by KLF2 directly binding to its promoter, thus hindering the … fly ba south africaWebDec 1, 2014 · Macrophages are the building blocks of intimal atherosclerotic lesions where they scavenge and accumulate modified lipoproteins, profoundly affecting lesion development and progression through their roles in lipid metabolism and as major sensors and effectors of the innate immune system. 1 Lesional macrophages originate from … greenhouse gas protocol corporateWebApr 30, 2024 · KLF2 is known to be upregulated in response to shear stress and to induce activation of numerous downstream signaling pathways that exert protective effects against atherosclerosis [28, 29]. However, expression of KLF2 is flow-dependent, and OSS had been shown to induce transient upregulation of KLF2 followed by prolonged suppression . To … fly bathroomWebNov 18, 2024 · KLF2 regulates metaflammation transcription in macrophages RNA-sequencing of bone marrow-derived macrophages (BMDMs) isolated from myeloid … fly bathurst to sydneyWebMar 26, 2024 · There are many crucial targets of KLF2, such as eNOS, THBD (thrombomodulin), number of pro-inflammatory, vasoconstrictive and pro-thrombotic genes (PAI1 (plasminogen activator inhibitor-1), SELE... fly batten roofWebAug 28, 2008 · KLF2 is a key regulator of endothelial and monocyte/macrophage proinflammatory action. 1,2 In endothelial cells, KLF2 expression is induced by laminar shear stress and inhibited by proinflammatory cytokines. Sustained overexpression of KLF2 results in marked induction of endothelial nitric oxide synthase (eNOS) and thrombomodulin … greenhouse gas protocol certification