WebJun 26, 2024 · SMR/HEIDI compares patterns of SNP-trait associations in the loci between two GWAS (in our case, GWAS for CAD and GWAS for gene expression). The analysis includes several steps of SNP filtration. WebJul 19, 2024 · The blue dots are the prediction correlations obtained with GWAS-significant SNPs (p-value < 5e-8) and SNP effects estimated from single-marker regressions (SMR). The pink-salmon curve shows the ...

Integration of summary data from GWAS and eQTL studies

WebMelanie F. Trask, MSOL, SHRM-CP Director of Academic Programs Clinical Research … WebApr 6, 2024 · SMR analyses for the DCAF17 gene revealed four eQTL signals with a significant SMR p -value. Out of these four eQTL signals, only one was significant in both SMR analyses ( p = 0.0024) and... supreme x nike tl

Investigating the potential anti-depressive mechanisms of statins: …

The SMR software tool was originally developed to implement the SMR & HEIDI methods to test for pleiotropic association between the expression level of a gene and a complex trait of interest using summary-level data from GWAS and expression quantitative trait loci (eQTL) studies ( Zhu et al. 2016 Nature Genetics ). WebSep 7, 2024 · SMR Analyses. Colocalization of GWAS signal with expression and methylation quantitative traits loci (eQTL and mQTL, respectively) was performed in a framework of the SMR v1.03 . In this, the GWAS summary result and eQTL data were used at the gene level to associate its expression level with a trait of interest. supreme x nike x acg