WebSingle chain vitamin K-dependent protein produced by osteoblasts. Osteocalcin purified from bovine bone. Binds to phospholipid vesicles in the presence of Ca 2+ (K d = 6 µM). Also binds hydroxylapatite. Possible role in bone mineralization, bone resorption, and bone formation. Note: Gla corresponds to γ-carboxyglutamic acid. WebMay 19, 1984 · Abstract. Mean (+/- SD) serum bone Gla-protein (BGP or osteocalcin) …
Osteocalcin: A link between bone, energy metabolism …
WebApr 4, 2024 · This gene encodes one of the most abundant non-collagenous proteins in … Matrix Gla protein (MGP) is member of a family of vitamin K2 dependent, Gla-containing proteins. MGP has a high affinity binding to calcium ions, similar to other Gla-containing proteins. The protein acts as an inhibitor of vascular mineralization and plays a role in bone organization. MGP is found in a number of … See more The MGP was linked to the short arm of chromosome 12 in 1990. Its mRNA sequence length is 585 bases long in humans. See more MGP and osteocalcin are both calcium-binding proteins that may participate in the organisation of bone tissue. Both have glutamate residues that are post-translationally carboxylated by the enzyme gamma-glutamyl carboxylase in a reaction that requires See more • matrix+Gla+protein at the U.S. National Library of Medicine Medical Subject Headings (MeSH) See more Abnormalities in the MGP gene have been linked with Keutel syndrome, a rare condition characterised by abnormal calcium deposition in cartilage, peripheral stenosis of the pulmonary artery, and midfacial hypoplasia. Mice that lack MGP … See more the nest family centre
Serum bone Gla-protein: a specific marker for bone …
WebApr 4, 2024 · This gene encodes a highly abundant bone protein secreted by … WebMay 1, 2024 · P, phosphorus; ALP, alkaline phosphatase; BGP, bone gal protein. Correlations Between Bone P Retention and Bone Development The correlation coefficients between bone P retention (the tibia ash P content and the total P accumulation in tibia ash) and bone development (the tibia BMC, BMD, breaking strength, and ash … Osteocalcin, also known as bone gamma-carboxyglutamic acid-containing protein (BGLAP), is a small (49-amino-acid ) noncollagenous protein hormone found in bone and dentin, first identified as a calcium-binding protein. Because osteocalcin has gla domains, its synthesis is vitamin K dependent. In humans, osteocalcin is encoded by the BGLAP gene. Its receptors include GP… the nest egg lubbock tx